Saturday, January 11, 2014

Zasetsky


L. Zasetsky was a technical student completing his education when World War II began and hurled Germany and Zasetsky's Soviet Union into battle. Like many other young men, Zasetsky became a soldier. Sublieutenant Zasetsky was 23 years old on the second of March 1943, the day a bullet entered his brain as he crossed the icy Vorya River. Zasetsky did not die. He received emergency surgery and then began a process of recovery that was to last for the rest of his life. He kept a written record, a pile of notebooks totalling over 3,000 pages and spanning three decades. These notebooks describe the effects of a terrible brain injury. Of his earliest days, he later wrote:

Right after I was wounded, I seemed to be some new-born creature that just looked, listened, observed, repeated, but still had no mind of its own. ...Because of my injury I'd forgotten everything I ever learned or knew. ...Mostly because of my memory that I have so much trouble understanding things. You see, I'd forgotten absolutely everything and had to start all over trying to identify, recall and understand things. ...

I'm in a kind of fog all the time, like a heavy half-sleep. My memory's a blank. I can't think of a single word. All that flashes through my mind are some images, hazy visions that suddenly disappear, giving way to fresh images. But I simply can't understand or remember what these mean.

Again and again I tell people I've become a totally different person since my injury, that I was killed March, 1943, but because of some vital power of my organism, I miraculously remained alive. Still, even though I seem to be alive, the burden of this head wound gives me no peace. I always feel as if I am living in a dream - a hideous, fiendish nightmare - that I am not a man but a shadow.
                                                                                                                  (Luria, 1972, pp. 10 - 12)

The story in Zasetsky's notebooks tells of a courageous, continuing effort to restore his lost mental functions. Zasetsky's torment illustrates clearly the critical importance of learning and memory in the normal activity of the human brain.
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''Every man's memory is his private literature''   ~  Aldous Huxley
 

Thursday, January 02, 2014

Cocaine: Wealth to a few, Misery to millions.

Cocaine is a global business. From coca farmers in Columbia, to trafficking cartels in Mexico, to crack slingers in Miami, to cocaine dealers in London, the supply chain of cocaine stretches around our world. For some cocaine is a way of life. Producers, traffickers, dealers, users, scientists, and cops are all part of this 300 billion dollar global industry.
 
Crack                      Powder
Cocaine, a powerful stimulant that produces feelings of intense pleasure and wellbeing, is used in two main forms. Cocaine powder, snorted predominantly by middle class and up. Many of whom would believe that it's non-addictive and can enhance both work and play. Crack cocaine is sold in rock crystal form that can be heated and inhaled or smoked. It is called 'crack' in reference to the cracking sound it makes when it is heated. It appeals to a lower class cohort due to it's price and availability and it delivers an intense high. However, smoking crack follows the laws of diminishing returns, the euphoria delivered by the first hit from a crack pipe is always the greatest. Users continue to smoke in an attempt to recapture the impact of that first hit.

The United Nations World Drug Report declares that there are up to 20 million cocaine users worldwide, with the majority snorting cocaine. Crack cocaine first emerged in 1984. Up until then, cocaine costing $100 per gram was seen as a drug that was the preserve of the rich. Crack revolutionised the cocaine business by offering a cheap, yet intensely powerful high for as little as $5. It soon swept through America's inner cities. Within a year, 5.5 million people had succumbed to this new addiction.
 

Cocaine has long been seen as
synonymous with a glamorous lifestyle
On the other side of the Atlantic in the U.K., crack cocaine has never really become as popular. The British population lean towards powdered form and use more than any other nation in Europe (EU Drug Agency Report). In the 1990's the appetite for cocaine in the U.K. exploded. Seen as a glamorous drug that enabled users to work and play harder and longer, cocaine became the drug of choice for Britain's middle class. Today, an estimated 38 tonnes of cocaine is being consumed in the U.K. each year.

Around the world there are an estimated two million people working as cocaine dealers. Selling cocaine in crack form can provide a good living but few make a fortune. The big fish are the traffickers who supply the dealers with the 900 tonnes of cocaine produced each year. They earn millions smuggling large shipments across international borders.
 
Cocaine dealt on the streets of London comes from the other side of the globe. From Columbia, cartels ship their product to depots they've built in Guinea Bissau, West Africa. The cocaine is then trucked to Morocco and into Spain, where it is sold to British traffickers who load it on trucks that are sent to the U.K. by ferry. Out of ten trucks, two are usually expected to be caught.
 
The cocaine trade wreaks havoc on countries around the world. Cash from the sale of coke has financed coups in Bolivia, fuelled guerrilla wars in Nicaragua and Columbia, and threatens the stability of the Mexican state today.

Every year 51 billion dollars worth of cocaine floods across the border into the United States. Mexican cartels purchase cocaine from Columbia where over half of the world's cocaine is produced. The cocaine produced by peasant farmers in Columbia is smuggled across the international borders by traffickers. Sold on city streets by dealers and to be snorted by the 1.9 million regular American users of cocaine. 360,000 of these are hard-core crack addicts. 25% of Americans who have used cocaine in the past year will develop a problem with it. Some will end up in prison and many will seek help for addiction.
 
Since 9/11, the U.S. department of homeland security reinforced it's border with Mexico by building hundreds of miles of fences and installing license plate readers at all points of entry. It's also increased border patrol units on land, sea, and air.
 
By the turn of the century, a wave of violence had spread through northern Mexico. The drug cartels fought each other for cocaine trafficking routes into the United States. In 2006 Felipe Calderon was elected president of Mexico. He pledged to take on and defeat the cartels responsible for plunging Mexico's northern cities into anarchy.


Felipe Calderon

Calderon dispatched state police and troops to crack down on the operations of the cartels. When Eduardo Arellano Felix (Tijuana Cartel) was arrested, the leadership vacuum sparked a war for control of the cartels and their drug smuggling routes into the U.S. With many looking to be 'top dog', the war is brutal. In the 3 years following Calderon's election, another 15,000 people are gunned down.



However, the deaths don't deter people  from entering into the illegal and violent drug trafficking business. There were hundreds eager to step into Eduardo's shoes and take over his trafficking routes by undermining his position. Up to 2013, the Mexican drug war has cost the lives of 60,000 people, with other reports putting it as high as 100,000 due to missing persons.
 
For the best part of the last 25 years, governments around the world have been fighting a war against cocaine. In Columbia, the American government has financed an eradication operation to reduce cocaine production in the country by 50%. Since 2000, the U.S government has poured five billion dollars into these eradication missions of cocaine superlabs, all to little effect. The amount of cocaine manufactured in Columbia remains the same today as at the beginning of the century.

No matter how many dealers are arrested, there will always be somebody else eager to take their place. Where there is demand, there will be a supply. Today, more cocaine enters the U.S. than ever before, with an army of dealers selling it to America's 7 million users and addicts. The war is relentless and the vast profits made from cocaine will undoubtedly continue to finance this global drugs business for the foreseeable future.
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''Cocaine is God's way of saying you're making too much money''.
                                                                                                    ~ Robin Williams

Monday, December 16, 2013

Christmas Carol Favourites - The Therapist and his Client

Schizophrenia ~ Do You Hear What I Hear?

Depressed ~ Driving Off A Cliff For Christmas...

Post Traumatic Stress Disorder ~ Grandma Got Run Over By A Reindeer...

Compulsive Gambler ~ Run Rudolph Run!!!

Passive Aggressive ~ All of the other reindeer used to laugh and call him names...

Agoraphobia ~ Hiding Behind The Christmas Tree, At The Christmas Party Hop...

Multiple Personality Disorder ~ We Three Queens Disoriented Are...

Alcoholic ~ All I Want For Christmas Is........To Get Sh*t-Faced!

Dementia ~ I Think I'll Be Home For Christmas...

Pyromaniac ~ Later on...we'll conspire...as we dream by the fire...

Tourette's ~ Jingle F**K! Jingle B****CKS!

Morbidly Obese ~ It's Beginning To Look A Lot Like...Diabetes !

Narcissistic ~ Hark The Herald Angels Sing About Me...

Body Dysmorphic ~ All I Want for Christmas.......is 6% Body-Fat And A Nose Job

Paranoid ~ Santa Claus Is Coming To.....Get Me !

Hypochondriac ~ He's making a complaint, He's checking it twice, He's not very happy with his doctor's advice...

Erotomania ~ The Twelve Dicks of Christmas...

Sadistic ~ Jingle Bells, Baseball Bats With Holes, The Safety Word is Sleigh...

Masochistic ~ Rudolph the Red-Arsed Reindeer...

Antisocial Personality Disorder ~ Last Christmas, I gave you my heart, the very next day you called me a scumbag, a maggot...

Social Phobia ~ Here Comes Santa Claus...Hide!

Borderline Personality Disorder ~ Thoughts Of Roasting On An Open Fire...

Personality Disorder ~ You Better Watch Out, I'm Gonna Cry, I'm Gonna Pout, Maybe I'll Tell You Why...

Insomniac ~ I'm.....Dreaming About....Sh*t All...


Manic ~ Deck The Halls and Walls and House and Lawn and Streets and Stores and Offices....


Obsessive Compulsive Disorder ~ Jingle Bells One, Jingle Bells Two, Jingle Bells Three, Jingle Bells Four, Jingle Bells Five, Jingle Bells Six, Jingle Bells Eight...Sh*t!...Jingle Bells One...


ADHD ~ He's Making A List, And Checking It Twice, Gonna Find Out...Do I Want Chicken Curry And Rice?

Exhibitionist ~ All I Want For Christmas...Is A Full Frontal !
 

 
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 ''The main reason Santa is so jolly is because he knows where all the bad girls live''                                                                                                                ~ George Carlin

Wednesday, November 13, 2013

Fancy some light reading?



The human genome is made up of 23 chromosome pairs with a total of about 3 billion DNA base pairs. It is the complete set of genetic information for humans. When the University of Leicester's Department of Genetics decided to print out an entire human genome, it amounted to 130 volumes of some 300 pages!!!
 
You - in 130 volumes
A total of 3000 million characters - and you thought Game of Thrones had a lot!


The genome print out spans 130 volumes, with each page printed on both sides in 4-point font, with about 43,000 characters per page. The X chromosome is made up of seven volumes, while the Y chromosome occupies one. The total exercise cost a little less than 4,000 pounds.
From start to finish it would take approximately 95 years to read!
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''DNA is like a computer program but far, far more advanced than any software ever created''
                                                                                                       ~ Bill Gates, The Road Ahead


Monday, November 04, 2013

Cocaine cues and dopamine

In 2006 at the Brookhaven National Laboratory, New York, a set of experiments was conducted to discover the true nature of cocaine addiction. Mexican born scientist, Prof Nora Volkow, is one of America's leading specialists on drug addiction. She's on a personal mission to understand the cause of addiction, driven by memories of her alcoholic uncle. ''He was rejected by the system...not even being accepted from the perspective of him having a medical disease''.
 
Prof. Nora Volkow
What fascinates Prof Volkow is the nature of cocaine addiction. As late as the 1980's, many scientists and politicians believed cocaine was non-addictive, and she wants to prove them wrong.
 
She took fMRI images of people under the influence of cocaine to try and identify areas of the brain, and the proteins in the brain that get disrupted by use of drugs in people that lose control of their drug intake at the expense of everything else in their life.
 
 
Her images showed that cocaine changes the brains structure. ''Repeated exposure produces changes in the way that the brain gets connected, and functions that result in pathological behaviour'', and this is why she argues in favour of it being regarded as a disease.
 
Trying to understand the nature of this disease, Prof Volkow scanned hundreds of users and ex-users. While scanning the brains of ex-users she noticed an irregularity. When subjects were discussing cocaine their dopamine levels rose. She argues that you could make a case that people become addicted to the lifestyle of cocaine use. Their brains have started to respond to the lifestyle, that is; the environment, their friends, and their situations. Her team later conducted experiments to test the theory.
 
Subjects were placed in an fMRI scanner and shown images of people preparing and snorting lines of cocaine. Viewing the images resulted in a significant increase of dopamine levels in the brains of the subjects who were current users.
 
The neurological effect of cocaine
''When we exposed them with stimulants that have been linked with drugs, what we observe is a significant increase in dopamine signalling in those areas of the brain that drive the motivation of drug behaviour''.
 
Prof Volkow's research showed that cocaine is so addictive that simply showing images of its use is enough to increase a subjects dopamine levels and lead them into a relapse.
 
Law enforcement treats cocaine users as criminals rather than people suffering from a disease. Over the past ten years, the government in the U.S. has repeatedly slashed funding for drug rehabilitation programmes and increased funding for prisons. The result: a million Americans are imprisoned on drug related charges, costing the American taxpayer 12.5 billion dollars per year.
 
Prof Volkow believes that the government's approach of criminalising and imprisoning drug use without proper treatment is misguided and statistics support her claims. Cocaine users are likely to relapse after leaving prison and end up re-incarcerated with 40% of cocaine users and 77% of crack convicts being re-offenders.
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Volkow, N.D., Wang, G.J., Telang, F., Fowler, J.S., Logan, J., Childress, A.R., Jayne, M., Ma, Y., Wong, C.J. (2006). Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. Journal of Neuroscience 14; 26 (24): 6583-8